The role of association of ADRB2 gene polymorphism with therapeutic response to β2-agonists in children with recurrent bronchial obstruction

Background. The study of the effect drugs at molecular genetic level in recurrent course bronchial obstruction (RBО) children improved understanding pathogenesis disease and made it possible to better characterize reliability use therapy. aim was assess clinical significance polymorphism Arg16Gly loci ADRB2 gene with a therapeutic response β2-agonists RBО Uzbek ethnicity. Materials methods. Tested 88 patients aged 6 15 years asthma determined effectiveness salbutamol these groups patients. Results. Results locus RBO showed high efficacy 72.9 % children, among whom representatives A/G A/A genotypes were found largest number. At same time, low greatest amount carriers mutational genotype G/G gene. Conclusions. predictor role polymorphic rs1042713 (Arg16Gly) unfavorable 46G allele gene, which marker children’s predisposition BA children. Children are risk for severe homozygous have incidence recurrence against background ARVI developing BA.